MENTAL HEALTH

Why the Brain Reaches for Relief

Davin Reed
Rhonda Howard
Lydia Armstrong

Author: Lydia Armstrong, PMHNP

Co-Author: Rhonda Howard, Ph.D.

Editor: Davin Reed

What “Relief” Actually Means

When we talk about using substances for “relief,” we’re not just talking about feeling good. We’re talking about escaping pain.

That pain might be:

  • Emotional (sadness, anxiety, anger, shame)
  • Physical (chronic pain, tension, exhaustion)
  • Psychological (trauma, intrusive thoughts, dissociation)
  • Existential (emptiness, meaninglessness, disconnection)

Substances provide relief by altering brain chemistry in ways that temporarily ease that pain. And when you’re in pain, relief—even temporary, destructive relief—feels necessary.

This isn’t weakness. It’s biology. It’s survival. Your brain is doing what brains do: seeking the fastest path away from suffering.

How Substances Hijack Brain Chemistry

Your brain has a reward system designed to reinforce behaviors that help you survive—eating, socializing, accomplishing goals.

When you do something beneficial, your brain releases dopamine, a neurotransmitter that makes you feel good. This reinforces the behavior: “Do that again.”

Substances hijack this system. They flood your brain with dopamine (or manipulate other neurotransmitters) in ways that natural rewards never could.

Different Substances, Different Effects:

Stimulants (Cocaine, Meth, Adderall)

Flood the brain with dopamine. You feel euphoric, energized, confident, invincible. Crashes are brutal—depression, exhaustion, irritability.

Opioids (Heroin, Fentanyl, Prescription Painkillers)

Mimic endorphins (natural pain relievers). You feel warm, numb, safe, pain-free. Withdrawal is agonizing—physical and emotional pain returns intensely.

Depressants (Benzodiazepines, Barbiturates)

Enhance GABA (calming neurotransmitter). You feel relaxed, less anxious, sedated. Tolerance and dependence develop quickly. Withdrawal can be life-threatening.

Cannabis

Affects cannabinoid receptors. You feel relaxed, less anxious, sometimes euphoric. Can worsen anxiety and motivation over time with heavy use.

Psychedelics (LSD, Psilocybin, MDMA)

Alter serotonin and perception. You feel connected, insightful, emotionally open. Not typically addictive but can be used to escape reality.

Each substance promises relief from something. The problem is: the relief is temporary, and the cost is high.

The Pain Underneath

Substance use is rarely the core problem. It’s a symptom.

Underneath the use, there’s usually pain:

Trauma

If you’ve experienced abuse, assault, neglect, or violence, substances can numb the memories, silence the flashbacks, and quiet the hypervigilance.

You’re not using to get high. You’re using to not feel the terror.

Mental Health Struggles

If you have untreated depression, anxiety, PTSD, ADHD, or bipolar disorder, substances can feel like self-medication.

  • Stimulants help you focus (ADHD)
  • Opioids numb emotional pain (depression)
  • Alcohol or benzos quiet anxiety
  • Cannabis helps you sleep (insomnia)

You’re not choosing to use—you’re trying to survive without adequate treatment.

Chronic Physical Pain

If you live with chronic pain and can’t access effective treatment, substances (especially opioids) can feel like the only option.

Loneliness and Disconnection

Humans are wired for connection. If you feel isolated, rejected, or fundamentally alone, substances can fill the void. They become your companion, your comfort, your escape from emptiness.

Hopelessness

If you’ve lost hope—if life feels unbearable and you can’t see a way forward—substances offer an exit. Not death, but a pause. A way to not be present.

Identity and Belonging

Sometimes substance use is tied to identity or community. You use because it’s part of your culture, your friend group, or the only place you feel like you belong.

The substance isn’t the problem. The pain, the isolation, the lack of support—that’s the problem.

What Substances Provide (Temporarily)

Substances meet needs that aren’t being met in healthier ways:

What Substances Provide What You Actually Need
Escape from emotional pain Therapy, emotional processing, trauma healing
Relief from anxiety Grounding techniques, medication, nervous system regulation
Energy and focus Sleep, nutrition, ADHD treatment, structure
Confidence and social ease Social skills practice, therapy for social anxiety, self-acceptance
Numbness from physical pain Medical care, pain management, physical therapy
Connection and belonging Healthy relationships, community, support groups
A sense of meaning or pleasure Hobbies, purpose, values-driven living

The substance is filling a gap. Recovery means identifying the gap and finding sustainable ways to fill it.

Why You Can’t “Just Stop”

People who’ve never struggled with substance use often say, “Just stop. It’s destroying your life.”

But it’s not that simple. Here’s why:

The Pain Is Still There

If you stop using without addressing the underlying pain, the pain comes roaring back—often worse than before. Your brain hasn’t learned other ways to cope.

Withdrawal Is Brutal

For many substances, stopping causes intense physical and psychological withdrawal:

  • Opioids: Flu-like symptoms, severe pain, anxiety, insomnia
  • Stimulants: Deep depression, exhaustion, suicidal thoughts
  • Alcohol/benzos: Seizures, tremors, life-threatening complications

Withdrawal isn’t just uncomfortable—it can be dangerous. Medical supervision is often necessary.

Your Brain Has Changed

Chronic substance use rewires the brain. Your reward system is dysregulated. You don’t feel pleasure from normal activities anymore. Everything feels flat without the substance.

This isn’t permanent, but it takes time to heal.

Your Life Is Built Around Use

If your social circle uses, if your routine revolves around obtaining and using, if your identity is tied to the lifestyle—stopping means losing everything familiar.

That’s terrifying.

Shame Makes It Harder

The more shame you feel, the more isolated you become. And isolation makes it nearly impossible to stop. Shame says, “You’re broken. You’re hopeless. You’ll never change.”

Shame doesn’t motivate recovery. It fuels continued use.

Finding Real Relief

Real relief doesn’t come from a substance. It comes from addressing the pain underneath.

Step 1: Acknowledge the Pain

What are you trying to escape? What hurts? What’s unbearable?

Naming the pain is the first step.

Step 2: Get Support

You can’t do this alone. Reach out to:

  • Therapist (especially trauma-informed or addiction specialists)
  • Doctor (for medication management, pain treatment, withdrawal support)
  • Support groups (NA, SMART Recovery, Refuge Recovery)
  • Trusted friends or family

Step 3: Address Co-Occurring Issues

If you have untreated mental health conditions, chronic pain, or trauma, those need to be addressed alongside substance use. Dual diagnosis treatment is essential.

Step 4: Build New Coping Tools

Learn to regulate your nervous system, process emotions, and tolerate distress without substances:

  • Therapy (CBT, DBT, EMDR)
  • Mindfulness and grounding techniques
  • Exercise and movement
  • Creative outlets
  • Connection and community

Step 5: Create a Life Worth Living

Substances filled a void. Recovery means building a life where that void no longer exists—a life with meaning, connection, purpose, and hope.

Your brain didn’t reach for substances because you’re weak. It reached for relief because you were in pain.

Real relief is possible. It just doesn’t come in a pill, a powder, or a bottle.

It comes from healing.

Last Reviewed:
Oct 25th 2025

Rhonda Howard, Ph.D.